Recent efforts in our lab have focused on complexes mediating DNA double strand break (DSB) repair ... is also interested in understanding the mechanism and regulation of homologous recombination ...

Both ends can be simply rejoined with little or no further processing (nonhomologous end joining, or NHEJ) or can be repaired using homologous ... double Holliday junction (double-strand break ...

They can also be produced when DNA replication forks encounter DNA single-strand breaks or other ... DNA DSBs are generated to initiate recombination between homologous chromosomes during meiosis ...

Since sister chromatids are identical to each other, recombination with a sister chromatid is expected, in most cases, to be a precise way for repairing DNA damage. Recombination between 2 different ...

Homologous recombination ... of meiotic homologous recombination. More information: Xinzhe Tang et al, In vitro ...

Their work, published in Nature Cancer, illustrates how a small DNA nick—a break in one strand of the DNA ... rather than failed DNA repair by homologous recombination, underpins the ...