In the alternate pathway initiated ... play a role in preventing recombination during DNA replication when it is not needed. An alternate hypothesis proposes that homologous chromosomes reside ...

Ovarian cancer (OC) is the fifth most common cause of cancer-related mortality worldwide and represents the leading cause of death for gynecological malignancies. Nevertheless, over the last years, ...

Combining BET inhibitors and PARP inhibitors might help patients resistant to chemotherapy, the study suggests.

As discussed above, 2 separate pathways play major roles in DSB repair in mammalian ... homology-directed repair is significantly impaired. Homologous integration of transfected DNA is also reduced.

The team showed that blocking homologous recombination changed the way the ... depends on the engagement of specific DNA repair pathways, particularly when radiation is given at very high, focused ...

Gene conversion is often associated with a nearby cross over, which suggests that these two events are the products of the same recombination pathway ... pairing of homologous genomes at meiosis ...

1998 Homology-directed repair is a major double-strand break repair pathway in mammalian cells ... 1999 Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination.

Different genomic alterations in DNA damage repair (DDR) pathways occur in 20% to 25% of advanced prostate cancer, including homologous recombination repair (HRR) gene alterations. Identifying the ...