In humans, one of the host cell’s first lines of defense against viral infection is the interferon system, a set of molecular cascades that can ultimately lead to the activation of hundreds of genes ...

Our cells harbor a DNA detector termed cGAS to inform the immune system of viral and bacterial infections, cell death, as ...

A research led by Sergio P. Acebrón, Researcher Ikerbasque at the UPV/EHU, develops a key tool to visualize the immune response to abnormal DNA, opening new avenues for the treatment of diseases.

St. Jude researchers identified a protein, voltage-dependent anion channel 2 (VDAC2), that tumors use as a “signal jammer” to prevent cancer cell death and evade the immune system’s functioning.

March 19, 2025) Targeted inhibition of a "signal jammer" protein may improve how tumors respond to immunotherapy. Published today in ...