A new study reveals that microRNAs—tiny regulators of gene expression—play a crucial role in shaping Purkinje cells, rare brain neurons linked to movement and neurodevelopmental disorders.

Our brains contain billions of neurons and trillions of connections, and scientists are only beginning to understand the ...

This regulation keeps glycolysis, the process by which cells convert glucose into energy, in Purkinje cells low, thereby ...

containing granule cell precursors (GCPs) and Purkinje cell (PC) layer. (D) Schematic showing GCPs (blue with black outline) in the external granule cell layer (EGL) and Nestin-expressing progenitors ...

In principle, this can be assessed by measuring the distinctive firing patterns, known as complex spikes, generated by Purkinje cells — the neurons that generate the output of the cerebellum.

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"Previously, research on cerebellar ataxias has primarily focused on the loss of cerebellar Purkinje cells. However, by the time cell loss occurs, therapeutic interventions are often ineffective ...

In this case, we combine electrophysiology, multi-photon imaging, and biophysical modeling to understand the computational function of changes in intrinsic excitability in cerebellar Purkinje cells.

The normal conduction system in the ventricles is called the His-Purkinje system and consists of cells that can conduct electricity quite rapidly. Thus, normal conduction of an electrical impulse ...