Since Kimura (1968) and King & Jukes (1969) first suggested that most polymorphisms are selectively neutral, testing the neutral hypothesis has been one of the prime objectives of molecular population ...
Abstract: Assumptions play a pivotal role in the selection and efficacy of statistical models, as unmet assumptions can lead to flawed conclusions and impact decision-making. In both traditional ...
Significance testing, with appropriate multiple testing correction, is currently the most convenient method for summarizing the evidence for association between a disease and a genetic variant.
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