Studies performed during the past 2 years have provided a deeper understanding into the role of CTLA-4, which is expressed ... additional peripheral regulatory mechanisms ensure that the ...

It is a drug that binds to the protein CTLA-4 to help immune cells kill ... TAK-500 has three possible mechanisms of action: activation of IFN response, reprogramming of suppressive intratumoral ...

However, tumor cells have developed sophisticated ways to evade detection, including hijacking the immune system’s brake mechanism, known as immune checkpoints ... Due to the inhibitory effects of ...

CS2009's mechanism of action ... CS2009 showed stronger anti-tumour effects than both PD-1/CTLA-4 and PD-1/VEGF bispecific antibodies; and in toxicology studies, CS2009 exhibited a safety margin ...

is a human Fc enhanced CTLA-4 blocking antibody designed to boost both innate and adaptive anti-tumor immune responses. Its novel design leverages mechanisms of action to extend immunotherapy ...