Their clinical AD data analysis began with a GWAS on a clinical AD cohort in which nearly half of participants had non-European ancestry, the dataset from the National Institute on Aging Genetics of ...

This new cryo-EM structure represents a remarkable advance in our understanding of how human PINK1 is stabilized” said ...

Do you know a conference you think we should list? Let us know by sending us an email with the details to [email protected].

Notably, microglia spatially associated with amyloid plaques exhibited increased expression of TREM2 and ApoE compared to such cells in non-immunized controls, regardless of whether the treatment was ...

Numerous studies have hinted that women are particularly susceptible to tau pathology, but scientists have lacked definitive data. Now, a meta-analysis of six longitudinal tau PET studies offers the ...

Autoimmunity and Alzheimer’s. People with autoimmune disorders in the UCSF (left) and Stanford medical systems (right) were ...

Despite growing recognition of the importance of the peripheral immune system in neurodegenerative disease, little is known about how these blood cells change in Alzheimer’s and Parkinson’s diseases.

The fragments also directly compromise synapses they encounter along the way, according to a preprint posted February 24 on bioRxiv. Specifically, tau fragments containing the microtubule binding ...

Protective borders between the brain and the blood weaken with age. This includes the barrier formed by tightly linked epithelial cells in the choroid plexus, which generates cerebrospinal fluid. In ...

Erythropoietin-producing hepatocellular (Eph) receptors, including EphA4, are expressed on the cell surface and involved in brain development, which involves extensive pruning of synapses. A variant ...