This important study provides solid evidence that glucosylceramide synthase (GlcT), a rate-limiting enzyme for glycosphingolipid (GSL) production, plays a role in the differentiation of intestinal ...

Checkpoint inhibitors are drugs that harness the immune system to destroy cancer cells. Let us review what’s been going on in the field.

Additional Phase 2 data for vilastobart,a tumor-activated, Fc-enhanced anti-CTLA-4, in combination with atezolizumab in patients with MSS CRC ...

DelveInsight’s, “Mesothelioma Pipeline Insight 2025” report provides comprehensive insights about 45+ companies and 50+ pipeline drugs in Mesothelioma pipeline landscape. It covers the Mesothelioma ...

A cogent example of this binary response is in the mobilization of co-stimulatory and co-inhibitory signaling in regulating the strength ... costimulatory molecule CD28 which is countered by CTLA-4.

The Witcher season 4 is on its way and it'll mark a huge new chapter in the Netflix show's saga. This time, we have a whole new Geralt of Rivia joining the fray as Liam Hemsworth becomes the White ...

Now and throughout history, queer people have always been able to find each other; in spaces that aren’t queer, queer signaling is and was often found through fashion, body language, voice ...

The Witcher 4 has now been officially revealed, with a new trailer confirming that the game will focus on Ciri as the main protagonist. This latest look does give us an idea as to the overall ...

CTLA-4 inhibitors stimulate T-cell activation and can help overcome ... Lapatinib enhances the therapeutic effects of T-DM1 by blocking signaling pathways that promote tumor cell survival, thus ...

We identified several polarization states of macrophages in synovium following joint injury, underpinned by distinct transcriptomic signatures, and regulated in part by stromal-derived macrophage ...